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Dr. Anette Casiano-Negroni

Clare Boothe Luce Assistant Professor of Chemistry


Courses Taught

CHEM 111 Fundamentals of Chemistry I
CHEM 350 Forensic Instrumental Analysis
NSCM 499 Divisional Seminar


  • B.Sc., Chemistry, University of Puerto Rico
  • M.Sc., Chemistry, University of Michigan
  • Ph.D., Chemistry/Biochemistry, University of Michigan


  • Alfred P. Sloan Foundation Fellow, 2005-2010


  • University of Michigan, Rackham Science Award, 2005
  • National Science Foundation Alliances of Graduate Education and Professoriate Travel, 2009

Select Works Published

  • Flipping of the ribosomal A- site adenines provides a basis for tRNA selection
    Zeng, X.; Chugh, J.; Casiano-Negroni, A.; Al-Hashimi, H.M.; Brooks, C.L., Journal of Molecular Biology, May 2014.,
  • Visualizing transient low- populated structures of RNA
    Dethoff E.A.; Petzold, K.; Chugh, J.; Casiano-Negroni, A.; Al-Hashimi, H.M., Nature, 2012, vol. 491, pp: 724-728,
  • NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P
    Koutmou, K.S.; Casiano-Negroni, A.; Getz, M. M.; Pazicni, S.; Andrews, A. J.; Penner-Hahn, J. E.; Al- Hashimi, H. M.; and Fierke, C. A, Proceedings of the National Academies of Sciences USA, 2010, vol. 107, pp: 2479-2484,
  • Characterizing µs-ms Exchange in Labeled and Unlabeled Nucleic Acids by Carbon R1? NMR
    Hansen, L.A.; Nikolove, N.E.; Casiano-Negroni, A.; Al-Hashimi, M.H., Journal of the American Chemical Society. Journal of the American Chemical Society, 2009, vol. 131, pp: 3818-3819,
  • Tryptophan- scanning of the Acetylcholine Receptor’s ?M4 Transmembrane Domain
    Díaz-De Leon, R; Otero-Cruz, J.D; Torres-Nuñez, D.A; Casiano, A.; Lasalde-Dominicci, J.A, Channels, 2008, vol. 2, pp: 1-10.,
  • Probing Na+ induced changes in the HIV-1 TAR Conformational Dynamics using NMR Residual Dipolar Couplings: New Insights into the Role of Counterions Ions and Electrostatic Interactions in Adaptive Recognition
    Casiano-Negroni, A.; Sun, X; Al-Hashimi, H.M., Biochemistry, 2007, vol. 46, pp: 6525-35,
  • NMR Studies of RNA Dynamics and Structural Plasticity using NMR Residual Dipolar Couplings
    Getz, M.; Sun, X; Casiano-Negroni, A.; Zhang, Q.; Al-Hashimi, H.M., Biopolymers, 2007, vol. 86, pp: 384-402,